Discussions

n order to act out the mechanisms of action of the tumour microenvironment in tumourigenesis, development, metastasis and treatment, or to assess the efficacy of tumour therapy in preclinical and clinical studies, the establishment of ideal tumour animal models provides a good alternative for scientific research and is an important part of antitumour research.

Service overview
In the service of genetic manipulation of H. pylori, we provide a selective culture service of H. pylori strains to help study the differences between different H. pylori strains. We also provide gene deletion or overexpression of specific H. pylori genes to help study the pathogenicity, virulence, and survivability of H. pylori. Then, in the service of gene editing of gastric cells and experimental animals, we provide the construction of gene-edited gastric cells and experimental animals to help study the interaction between H. pylori and the host.

Introduction to Cell-Based Protein Expression
Methods of producing or manufacturing functional proteins are necessary to study the biological roles of proteins of interest. Protein expression can be used across diverse areas of life science research. It has been the core activity of high throughput screening, functional validation, and structural biology. Many synthetic biology methods also rely on protein expression.

Omics in Rare Disease
Omics in rare diseases allows researchers to gain a comprehensive understanding into the pathogenesis of rare diseases from DNA, RNA and proteins that containing a huge amount of information by the application of various omics technologies, including genomics, epigenomics, transcriptomics, proteomics and metabonomics. The potential therapeutic targets are destined to be identified from the complex molecular networks and pathways.

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Food preservation products refer to the products used in food to prevent the deterioration of food due to microbial propagation during storage and circulation, or the deterioration of the internal quality of food due to poor storage and sales conditions, and the decline of color, so as to improve the storage period and extend the edible value. In addition to some commonly used chemical reagents for food preservation, the extraction of some active ingredients from natural sources of animals, plants and microorganisms has also attracted extensive attention, and these active ingredients are more easily accepted by consumers because of their green and safe sources.

Food preservation involves making food more resistant to microbial growth, slowing down the process of fat oxidation and maintaining a certain amount of moisture. Food preservation may also include inhibiting visual spoilage processes, such as the enzymatic browning reaction after apples are cut during food preparation. By preserving food, food waste can be reduced, which is an important way to reduce production costs and increase the efficiency of food systems, improve food safety and nutrition, and contribute to environmental sustainability.

Gene methylation, gene mutations, and protein markers are commonly used biomarkers for brain tumor diagnosis. However, the mechanisms of brain tumorigenesis are complex, and a large number of studies have demonstrated the limitations of relying on single omics, as the analysis of single-level data can only provide little cause-and-effect relationships. In contrast, a multi omics data integration strategy spanning genomic, transcriptomic, proteomic, and metabolomic levels of different cellular functions has the potential to provide unparalleled insights into the underlying biology of brain tumors.

Tumor neoantigen is a new direction of tumor treatment, and it is a truly personalized treatment plan. During the growth of cancer cells, a series of DNA-specific mutations are often accompanied by a series of DNA-specific mutations, stimulating cancer cells to develop drug resistance or rapid growth, and this specific mutation is different in tumor cells of different patients, making traditional tumor drugs less effective. Tumor neoantigens are protein or polypeptide fragments produced by tumor cell-specific mutations, which have individual differences and immune tolerance, and are ideal targets for drugs and treatments. Tumor neoantigen drugs represent a new direction for tumor treatment, and the application of relevant drugs and the implicit approval of clinical trials mark that personalized precision therapy has entered the clinical stage.

Introduction
Tumors involve cellular alterations, including growth and division that take cells out of their normal limits, leading to invasion and destruction of adjacent tissues and eventual metastasis to distant sites in the body. Oncology researchers need better research tools that allow them to more easily study the complex, unknown interactions between tumor cells and their environment and identify points of therapeutic intervention for tumors.