Discussions

The radionuclide is an essential part of the acting part of RDC (Radionuclide Drug Conjugate), which can play a role in killing cancer cells and diagnostic imaging. Types of radionuclides are approved for application in RDC nowadays.

Rdcthera, as a professional CRO company, can provide radionuclide synthesis service. Since we have synthesis services for a wide range of radionuclides, we are capable of radionuclide screening to find the most suitable radionuclide in your specific RDC development.

Overview of Radionuclides
The radioactive particle is the effective part of the radiopharmaceutical, which can emit β- or α- beams to deliver radiation directly to the tumor cells. For a given chemical element, radionuclides have the same number of protons in each atom, but they have different numbers of neutrons. In theory, all chemical elements in nature can exist as radionuclides.

As the radionuclide is too small to be stable in patients, it can be chelated with antibodies, small molecules, and peptides to maintain stability. A myriad of radionuclides has been conjugated with ligand applied for clinical research. The radionuclide in RDC works as the cell-damaging tool and the diagnostic tool imaging by PET or SPECT. There are three types of radionuclides that are most commonly used in RDC.

Source: https://www.rdcthera.com/radionuclide-screening-and-synthesis-service.html